Presented by visiting international guests Thomas Jaki and James Wason, the full day pre-conference workshop on adaptive trials is open to all.
Master protocols are a class of efficient clinical trial designs that seek to answer multiple research questions within a single trial protocol and include platform, basket and umbrella trials. The advantages of using such designs are many, ranging from use of a shared trial infrastructure to reusing information within the study (e.g. using a single control group or borrowing of information).
In this course we provide an overview of statistical approaches to the design and analysis of Master protocols in a mixture of lectures and practical sessions. The following topics will be discussed:
· A framework for designing multi-arm multi-stage platform trials
· Methods for information borrowing with application to Basket and Umbrella trials
· Software for Master protocols
· Practical considerations when implementing a Master protocol
Tutors
Professor Thomas Jaki - Professor of Statistics at University of Regensburg and Professor of Statistics at University of Cambridge
Professor James Wason – Professor of Biostatistics at Newcastle University
Latest Resources
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Webinar recording: APT Virtual Clinic – ED Asthma and CAPTIVATE
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Webinar recording: APT Virtual Clinic – ACT-GLOBAL Adaptive Platform Trial for Stroke
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Webinar recording: APT Virtual Clinic – UNSW / Black Dog Institute on Treatment-Resistant Depression
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Webinar recording: APT Virtual Clinic – PLATIPUS: A Platform for Adaptive Trials in Perinatal Units
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Webinar recording: APT Virtual Clinic – Schizophrenia Platform for Improving Recovery with Integrated Trials
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Adaptive Design Clinical Trials
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Workshops and Virtual Clinics on Adaptive Platform Trials
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Webinar recording: APT Virtual Clinic – the BAT and PASSPORT Trials
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Exploring greater partnership between Clinical Trial Networks, Clinical Quality Registries and Trial Coordinating Centres with Industry
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Adaptive Platform Trial Summaries
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HEAT Webinar Recording- Economic Evaluation Alongside Adaptive Trials
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Protocols and Statistical Analysis Plans (SAPs) for Adaptive and Platform Trials
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Data and Safety Monitoring Boards Webinar Series: Statistical Principles
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Data and Safety Monitoring Boards Webinar Series: How to plan well and be prepared for the unexpected
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Statistical Analysis Plan (SAP)
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What are the benefits of adaptive designs?
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How do adaptive trial sizes work?
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What is an adaptive clinical trial?
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What is response adaptive randomisation?
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Data Safety and Monitoring Boards (DSMB) for Adaptive Trials Webinar video
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Data Safety and Monitoring Boards (DSMB) for Adaptive Trials Webinar slides
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Bayesian adaptive randomised clinical trials flyer
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Adaptive Design Clinical Trials
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Hackathon of Novel Trial Designs part two
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Hackathon of Novel Trial Designs part one
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Studies Within A Trial SWATs webinar
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Innovative Trial Design and Conduct Reference Group Objectives and Directions
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Novel approaches to healthcare effectiveness research outside Australia
Latest Events
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ACTA Virtual Clinics on Adaptive Platform Trials 2024
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ACTA Virtual Clinics on Adaptive Platform Trials
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ACTA Virtual Clinics on Adaptive Platform Trials – 14 Sept 23
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ACTA Virtual Clinics on Adaptive Platform Trials – 13 July 23
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ACTA Virtual Clinics on Adaptive Platform Trials
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Economic Evaluation Alongside Adaptive Trials webinar – 22 November
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Improving clinical trial recruitment through innovative technologies
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Practical approaches to Adaptive Trial Simulation
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An Introduction to Adaptive Trial Designs
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Seven steps for statistical success in clinical trials [Good clinical practice guidelines] Part 1
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Statistical principles – Data and Safety Monitoring Boards Webinar Series
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How to plan well and be prepared for the unexpected – Data and Safety Monitoring Boards Webinar Series
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Webinar: Data Safety and Monitoring Boards for Adaptive Trials
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Bayesian Adaptive Randomised Clinical Trials Workshop, Sydney
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Bayesian Adaptive Randomised Clinical Trials Workshop, Melbourne
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Bayesian Adaptive Trials Workshops: Perth
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Workshop: Pragmatic randomised trial designs for evaluating health policy and practice change interventions