ACTA STInG is a group of more than 150 statisticians and clinicians with an interest in statistics in clinical trials.
- To improve the quality of clinical trials within Australia by strengthening links among trial statisticians.
- To develop a structured support network for trial statisticians across Australia, within which different centres provide specialist support for particular trial designs or clinical areas.
- To work with ACTA to increase recognition and advocate within the research community (including ethics committees and with the NHMRC) for the importance of professional statistical support in the conduct of trials.
- To promote collaborative methodological research among trial statisticians in clinical trial design and analysis.
- To promote professional standards of statistics in trials and where possible harmonise attitudes to the practice of statistics in clinical trials settings within Australia.
- To develop a strategy for training and mentoring future generations of trial statisticians within Australia.
The executive committee of this group is very engaged and meets frequently to advance the initiatives of the group. ACTA STInG also releases a newsletter twice a year. ACTA STInG has no activity funding, so the group works through in-kind support and voluntary coordination.
STInG members are invited to view two online directories: the find a statistician directory that include details of statisticians who may be available for support and collaboration on specific topics within trial design and analysis, with the aim of proving a support network for statistician, and a DSMB directory which provides a list of statisticians who may be willing to be on a Data and Safety Monitoring Board (DSMB)
Directories
DSMB mentoring program
STInG have established a mentoring program to facilitate and support training for statisticians in the role of a DSMB statistician. Through this program, statisticians wishing to gain experience in DSMBs are paired with an experienced statistician and shadow their role on a DSMB
Membership
If you would like to become a member of ACTA STInG, please fill out this form.
- Guidance for trial statisticians planning to apply for an academic promotion
- Guidance on peer reviewing the statistical aspects of a medical paper
- PANDA – A Practical Adaptive & Novel Designs and Analysis toolkit
Estimands
- Estimating the treatment effect for adherers using multiple imputation
- ICH E9(R1) Estimands and Sensitivity Analysis in Clinical Trials Training Module 1: Summary
- Estimands and Complex Innovative Designs
- Incorporating estimands into clinical trial statistical analysis plans
- Estimands: bringing clarity and focus to research questions in clinical trials
Our 2022 ACTA STInG Award winner
The PADDI Trial
- Chief Investigator: Prof Tomás Corcoran
- Network or investigator group: Australian and New Zealand College of Anaesthetists
(ANZCA) Clinical Trials Network - This trial presented that dexamethasone can be safely administered to patients to
prevent nausea and vomiting when undergoing surgery, without concern about wound
infections. - View the SAP
Our 2021 ACTA STInG Award winner
The PEPTIC Trial
- Chief Investigator: Prof Andrew Forbes
- Network or investigator group: ANZICS Clinical Trials Group (Australian and New Zealand Intensive Care Society)
- This trial studied the effect of stress ulcer prophylaxis with proton pump inhibitors vs. Histamine-2 receptor blockers on in hospital mortality among ICU patients with invasive mechanical ventilation
- View the SAP
Our 2020 ACTA STInG Award winner
The ENZAMET Trial
- Chief Investigators: Prof Ian Davis and Prof Christopher Sweeney
- Network or investigator group: ANZUP Cancer Trials Group
- The ENZAMET trial was designed to test whether survival of men with metastatic prostate cancer could be improved even further by adding enzalutamide to hormone therapy right at the beginning of treatment, instead of waiting for the cancer to grow after prior hormone treatment.
- View the SAP
Latest Resources
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Career paths for academic biostatisticians
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ACTA STInG: N-of-1 Trials Webinar Series – Webinar 2
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ACTA STInG: N-of-1 Trials Webinar Series – Webinar 1
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Webinar PIONEERing estimands in Clinical Research
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Estimands: Not just a statistical issue
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Resource for trial statisticians planning to apply for an academic promotion
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Guidance on Peer Reviewing the Statistical Aspects of a Medical Paper
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Protocols and Statistical Analysis Plans (SAPs) for Adaptive Trials
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Webinar: Estimands in Oncology – How and Why
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Joint webinar on estimands in clinical trials
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Statistical Analysis Plan (SAP)
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Bayesian adaptive randomised clinical trials flyer
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ACTA STInG Notes from Members’ meeting, October 2019
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ACTA STInG 2017 Member Survey Results
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ACTA STInG Submission to the NHMRC Structural Review
Latest News
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STInG November 2023 newsletter
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Successful 2021 ACTA ASM
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ACTA STInG: signatories to open letters addressing statistical analysis and data integrity in COVID-19 publications
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STInG May newsletter
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Nominations extended for ACTA Trial of the Year Awards
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International experts head to Melbourne and Sydney for Bayesian Adaptive Trials Workshop
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ACTA—a year in review, 2018-2019 financial year
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STInG November Newsletter
Latest Events
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ACTA STInG- Stata and R Markdown Demonstrations
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ACTA STInG 3 part webinar series on Data Transparency (DT)
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Clinical Trials 2021: National Tribute and Award Ceremony
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Clarifying clinical trial aims and analysis using the estimands framework
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Seven steps for statistical success in clinical trials [Good clinical practice guidelines] Part 2
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Seven steps for statistical success in clinical trials [Good clinical practice guidelines] Part 1
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Statistical principles – Data and Safety Monitoring Boards Webinar Series
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How to plan well and be prepared for the unexpected – Data and Safety Monitoring Boards Webinar Series
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Webinar: Data Safety and Monitoring Boards for Adaptive Trials
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Bayesian Adaptive Randomised Clinical Trials Workshop, Sydney
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Bayesian Adaptive Randomised Clinical Trials Workshop, Melbourne
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Bayesian Adaptive Trials Workshops: Perth