The number of clinical trials in Australia that are using adaptive methods is increasing.
ACTA Innovative Trial Design Reference Group and ACTA STInG leadership group are heavily involved in these trials and are working to ensure that similar professionals remain connected and have access to continuing professional development opportunities.
One of the challenges associated with adaptive trials is ensuring that the Data Safety and Monitoring Board (DSMB) functions effectively.
Investigators who are planning or conducting adaptive trials can benefit from better understanding of the unique role DSMBs play in these trials.
To help address this knowledge gap, ACTA is hosting a webinar in conjunction with Dr Scott Berry and Dr Michelle Detry from Berry Consultants. Scott and Michelle are world-leaders in the design, conduct, analysis and reporting of investigator-initiated as well as commercially sponsored adaptive trials.
The webinar will outline issues associated with composition, role and processes for the DSMB as well as issues related to pre-specifications in the trial protocol, DSMB section of the trial protocol, DSMB charter, statistical analysis team and trial management team.
It is aimed at clinical researchers, clinical trialists and statisticians.
The webinar will wrap up with a Q and A session which will give participants an opportunity to interact with Scott and Michelle.
Latest Resources
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ACTA STInG: N-of-1 Trials Webinar Series – Webinar 1
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ACTA 2021-2022 Annual Report
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Joint webinar on estimands in clinical trials
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Webinar PIONEERing estimands in Clinical Research
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Estimands: Not just a statistical issue
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Resource for trial statisticians planning to apply for an academic promotion
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ACTA 2020-2021 Annual Report
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Guidance on Peer Reviewing the Statistical Aspects of a Medical Paper
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Protocols and Statistical Analysis Plans (SAPs) for Adaptive Trials
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Data and Safety Monitoring Boards Webinar Series: Statistical Principles
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Data and Safety Monitoring Boards Webinar Series: How to plan well and be prepared for the unexpected
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Statistical Analysis Plan (SAP)
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What are the benefits of adaptive designs?
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How do adaptive trial sizes work?
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What is an adaptive clinical trial?
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What is response adaptive randomisation?
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Data Safety and Monitoring Boards (DSMB) for Adaptive Trials Webinar video
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Data Safety and Monitoring Boards (DSMB) for Adaptive Trials Webinar slides
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Bayesian adaptive randomised clinical trials flyer
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ACTA STInG grant advice for trial statisticians
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ACTA STInG Notes from Members’ meeting, October 2019
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Adaptive Design Clinical Trials
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Hackathon of Novel Trial Designs part two
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Hackathon of Novel Trial Designs part one
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Studies Within A Trial SWATs webinar
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Innovative Trial Design and Conduct Reference Group Objectives and Directions
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ACTA STInG 2017 Member Survey Results
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Novel approaches to healthcare effectiveness research outside Australia
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ACTA STInG Submission to the NHMRC Structural Review
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ACTA STInG- Stata and R Markdown Demonstrations
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ACTA STInG 3 part webinar series on Data Transparency (DT)
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Clinical Trials 2021: National Tribute and Award Ceremony
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Clarifying clinical trial aims and analysis using the estimands framework
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Practical approaches to Adaptive Trial Simulation
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An Introduction to Adaptive Trial Designs
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Seven steps for statistical success in clinical trials [Good clinical practice guidelines] Part 2
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Seven steps for statistical success in clinical trials [Good clinical practice guidelines] Part 1
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Statistical principles – Data and Safety Monitoring Boards Webinar Series
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How to plan well and be prepared for the unexpected – Data and Safety Monitoring Boards Webinar Series
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Bayesian Adaptive Randomised Clinical Trials Workshop, Sydney
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Bayesian Adaptive Randomised Clinical Trials Workshop, Melbourne
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Bayesian Adaptive Trials Workshops: Perth
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Workshop: Pragmatic randomised trial designs for evaluating health policy and practice change interventions