The clinical trials landscape is rapidly evolving, marked by advancements that are reshaping the approaches to medical research. The increased use of innovative trial designs such as Adaptive Platform Trials are making trials more flexible, efficient and responsive to emerging data. In light of these developments, ACTA has established a registry of resources for innovative trial designs, as well as a special interest group dedicated to supporting and advancing these novel methodologies. APTO SIG aims to foster collaboration, share knowledge, and support the implementation of Adaptive Platform Trials to improve the efficiency and quality of clinical trials in Australia.
- Share common key challenges and opportunities for innovative trial designs, specifically adaptive platform trials
- Provide and explore best practice knowledge and resource opportunities
- Explore ways to support and foster growth of the adaptive platform trial operations workforce
- Develop informative and relevant resources for adaptive platform trial operations teams.
Membership
APTO SIG comprises a variety of disciplines across various Adaptive Platform Trials in Australia, from early stages of design through completion. Membership is open to project managers, clinical trial clinicians, registered nurses, data managers, data systems developers and other specialist operational skills, who are currently working on an APT or have significant experience with APTs.
For a list of Adaptive Platform Trials currently represented in our group membership, please click here.
Are you involved in an Adaptive Platform Trial in an operational capacity, or keen to learn more? Express your intrest to join APTO SIG here.
Latest Resources
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Information and resources on Adaptive and Platform Trials for consumer representatives
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Innovative trial design glossary
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Webinar recording: APT Virtual Clinic – the PANTHER trial
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Adaptive platform trials: Efficiencies and Complexities
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Webinar recording: APT Virtual Clinic – SEISMIC and IVCare
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Webinar recording: APT Virtual Clinic – ED Asthma and CAPTIVATE
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Webinar recording: APT Virtual Clinic – ACT-GLOBAL Adaptive Platform Trial for Stroke
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Webinar recording: APT Virtual Clinic – UNSW / Black Dog Institute on Treatment-Resistant Depression
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Webinar recording: APT Virtual Clinic – PLATIPUS: A Platform for Adaptive Trials in Perinatal Units
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Webinar recording: APT Virtual Clinic – Schizophrenia Platform for Improving Recovery with Integrated Trials
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Adaptive Design Clinical Trials
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Novel technologies for clinical trial recruitment in Australia
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Workshops and Virtual Clinics on Adaptive Platform Trials
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Webinar recording: APT Virtual Clinic – the BAT and PASSPORT Trials
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Exploring greater partnership between Clinical Trial Networks, Clinical Quality Registries and Trial Coordinating Centres with Industry
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Protocols and Statistical Analysis Plans (SAPs) for Adaptive and Platform Trials
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Data and Safety Monitoring Boards Webinar Series: Statistical Principles
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Data and Safety Monitoring Boards Webinar Series: How to plan well and be prepared for the unexpected
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Statistical Analysis Plan (SAP)
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What are the benefits of adaptive designs?
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How do adaptive trial sizes work?
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What is an adaptive clinical trial?
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What is response adaptive randomisation?
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Data Safety and Monitoring Boards (DSMB) for Adaptive Trials Webinar video
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Data Safety and Monitoring Boards (DSMB) for Adaptive Trials Webinar slides
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Bayesian adaptive randomised clinical trials flyer
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Adaptive Design Clinical Trials
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Hackathon of Novel Trial Designs part two
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Hackathon of Novel Trial Designs part one
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Studies Within A Trial SWATs webinar
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Innovative Trial Design and Conduct Reference Group Objectives and Directions
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Novel approaches to healthcare effectiveness research outside Australia
Latest News
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AusTriM Innovative Methods in Trials – Design & Analysis Collaboration Opportunity
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Webinar wrap-up: Data Safety and Monitoring Boards for Adaptive Trials
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International experts head to Melbourne and Sydney for Bayesian Adaptive Trials Workshop
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ACTA Webinar: Scott Berry on the FDA Adaptive Trial Guidance
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ACTA Hackathon of Novel Trial Designs webinars: 1 and 15 May
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Announcing ACTA’s new Summer School and Weekly Webinars
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ACTA’s Innovative Trial Design and Conduct Reference Group innovates into two
Latest Events
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ACTA Virtual Clinics on Adaptive Platform Trials 2024
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Platform trials and master protocols – Workshop
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Improving clinical trial recruitment through innovative technologies
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Practical approaches to Adaptive Trial Simulation
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An Introduction to Adaptive Trial Designs
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Seven steps for statistical success in clinical trials [Good clinical practice guidelines] Part 1
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Statistical principles – Data and Safety Monitoring Boards Webinar Series
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How to plan well and be prepared for the unexpected – Data and Safety Monitoring Boards Webinar Series
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Webinar: Data Safety and Monitoring Boards for Adaptive Trials
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Bayesian Adaptive Randomised Clinical Trials Workshop, Sydney
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Bayesian Adaptive Randomised Clinical Trials Workshop, Melbourne
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Bayesian Adaptive Trials Workshops: Perth
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Workshop: Pragmatic randomised trial designs for evaluating health policy and practice change interventions