Presented by visiting international guests Thomas Jaki and James Wason, the full day pre-conference workshop on adaptive trials is open to all.
Master protocols are a class of efficient clinical trial designs that seek to answer multiple research questions within a single trial protocol and include platform, basket and umbrella trials. The advantages of using such designs are many, ranging from use of a shared trial infrastructure to reusing information within the study (e.g. using a single control group or borrowing of information).
In this course we provide an overview of statistical approaches to the design and analysis of Master protocols in a mixture of lectures and practical sessions. The following topics will be discussed:
· A framework for designing multi-arm multi-stage platform trials
· Methods for information borrowing with application to Basket and Umbrella trials
· Software for Master protocols
· Practical considerations when implementing a Master protocol
Professor Thomas Jaki - Professor of Statistics at University of Regensburg and Professor of Statistics at University of Cambridge
Professor James Wason – Professor of Biostatistics at Newcastle University