This document is intended to identify issues and, where appropriate, provide options and recommendations for how adaptive platform trials (APTs) might be funded in Australia.
About Adaptive Platform Trials (APTs)
APTs focus on a disease or condition rather than an intervention and permit more rapid generation of evidence than conventional trial designs because a large number of clinical questions can be addressed within a single platform.
The flexible designs and use of common control arms are attractive to both researchers and funding agencies but add complexity in terms of trial design, statistical modeling, trial conduct and operations, digital technology and trial governance.
Who is this paper for?
The primary audience is federal and state or territory government agencies that fund clinical trials, including but not limited to the MRFF and NHMRC, although this document also has relevance for philanthropic organisations and the healthcare system more broadly.
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