The main objective of the talk is to discuss the challenges of stopping trials early for benefit. We will use the immediate Kangaroo Mother Care (iKMC) trial recently published in NEJM as an example to address the following issues: a) How robust is the evidence from trials stopped early for benefit? b) When is it appropriate to stop trial early for benefit? c) Knowing that stopping early is associated with biases, how can we optimize our approach monitoring of trials to avoid this? d) How do we balance the ethics of stopping early vs the pursuit of scientific truth of getting it right? e) What are the scientific implications of stopping early? f) What are the ethical implications of not stopping early given the importance of adhering to the trial protocol?
Presenter

Dr Lehana Thabane
Dr. Lehana Thabane is a Vice President of Research at St Joseph’s Healthcare—Hamilton and St Joseph’s Health System; Scientific Director of the Research Institute at St Joseph’s Healthcare; Professor of Biostatistics in the Department of Health Research Methods, Evidence, and Impact at McMaster University. He is a Fellow of theRoyal Society of Canada, Fellow of the American Statistical Association, Fellow of the Society for Clinical Trials, Fellow of the Canadian Academy of Health Sciences, and Honorary Foreign Associate Member of the Academy of Science of South Africa. He is the Past President of the Society for Clinical Trials. He is the recipient of the 2022 of the Statistical Society of Canada Award for Impact of Applied and Collaborative Work. He was a recipient of an honorary degree from Stellenbosch University in South Africa in December 2023 for his contribution to clinical trial methodology.
Dr Thabane is the Emeritus Founding Editor-in-Chief of the journal Pilot and Feasibility Studies; and he is a member of the editorial board for many journals including Trials, and BMJ Open. He has co-authored over 1200 peer-reviewed manuscripts leading to significant contributions and transformation of science, healthcare, and delivery of care in many clinical areas. Having mentored over 200 graduate students and junior faculty, Dr Thabane has won several teaching and mentorship awards for his commitment to building capacity in health research and nurturing the next generation of researchers.
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