N-of-1 trials are experiments in which patients are systematically allocated to repeated episodes of treatment with interventions, typically pharmaceuticals, whose effects are being compared. Traditionally, n-of-1 trials have been analysed independently on a patient by patient basis but this four-lecture course will consider the design and analysis of sets of n-of-1 trials, that is to say involving many patients, with various objectives, for example, not only to study the average effects of treatments but also to identify differences in individual response.
The emphasis of the course will be practical and philosophical and mathematical development will be kept to a minimum. Analysis in R, SAS and Genstat will be covered.
Webinar 1- 18th April 5-6:30pm AEST
This webinar will introduce the topic and consider some relevant history. This session will concentrate on using n-of-1 trials to estimate average treatment effects and will consider both randomisation approaches and fixed linear models.
Design and Analysis of N of 1 Trials – Lecture 1
Design and Analysis of N of 1 Trials – Lecture 2
About the Presenter:
Professor Stephen Senn
Originally from Switzerland, Stephen Senn was head of the Competence Center for Methodology and Statistics at the Luxembourg Institute of Health in Luxembourg, 2011-2018, Professor of Statistics at the University of Glasgow, from 2003 to 2011, and Professor of Pharmaceutical and Health Statistics at University College London from 1995-2003. He has also worked in the Swiss pharmaceutical industry, as a lecturer and senior lecture in Dundee and for the National Health Service in England. He is the author of the monographs Cross-over Trials in Clinical Research (1993, 2002), Statistical Issues in Drug Development (1997, 2007, 2021) and Dicing with Death (2003, 2022) and over 300 scientific publications. In 2001 Stephen Senn was the first recipient of the George C Challis award for Biostatistics of the University of Florida, in 2008 he gave the Bradford Hill lecture of the London School of Hygiene and Tropical Medicine and in 2009 was awarded the Bradford Hill Medal of the Royal Statistical Society. In 2017 he gave the Fisher Memorial Lecture. He is a Fellow of the Royal Society of Edinburgh and an honorary life member of Statisticians in the Pharmaceutical Industry (PSI) and the International Society for Clinical Biostatistics. He is an honorary professor at the University of Sheffield. He retired in 2018 but is still researching and consulting in statistics.