ACTA Webinar - Adaptive Allies: The Evolving Roles of DSMBs and Investigators in Bayesian Platform Trials - Part 3

The growing adoption of Bayesian adaptive designs in clinical research is reshaping and expanding the roles of both DSMBs and trial investigators. This webinar explores the dynamic collaboration between DSMBs and investigators, focusing on how almost real-time data, adapting trial design, ongoing publications of selected results and ethical oversight intersect in platform trials. Join us as we unpack practical challenges, communication pathways, and governance strategies essential to safeguarding trial integrity while maximising efficiency and innovation. Key topics will include prioritising data quality, managing information flow, maintaining trial integrity, implementing adaptations based on decision criteria, and aligning safety monitoring with evolving trial evidence. The session will highlight case examples and emerging best practices to support robust oversight in a dynamic trial landscape.

Presenters

Tom Snelling - University of Sydney

Tom Snelling is a clinical scientist, Director of Health and Clinical Analytics in the School of Public Health at the University of Sydney, and an infectious diseases physician in the Sydney Children’s Hospitals Network. Tom has particular interest in vaccine preventable diseases and application of decision theory to research design. He leads a team of researchers aiming to improve healthcare and reduce the burden of infectious disease by implementing learning health systems. Tom applies Bayesian approaches to the design, implementation, and analysis of public health studies, and is successfully leading a suite of multi-institutional collaborative projects across Australia covering a range of clinical domains. These include: improving treatment and prevention of severe gastroenteritis in remote Aboriginal children, primary prevention of food allergies in children, SMS text messages to improve timeliness of routine immunisation, and improving management of cystic fibrosis.

Julie Marsh - The Kids Research Institute

Julie Marsh is the biostatistical lead in the Adaptive Health Intelligence team based in the Wesfarmers Centre of Vaccines and Infectious Diseases at The Kids Research Institute (closely affiliated with the Health and Clinical Analytics lab at the University of Sydney) and is an adjunct A/Prof in the Faculty of Medicine at the University of Western Australia. She is a nationally recognised and highly-regarded consultant statistician with over 25 years’ experience in clinical trials. Her current research areas are the design, implementation and analysis of Bayesian adaptive trials and vaccine safety surveillance. She has contributed to the national implementation of 15 clinical trials using Bayesian adaptive designs, the implementation of a national vaccine safety surveillance system, and the delivery of educational materials and training workshops on adaptive trials to up-skill Australian trialists.

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