Major depressive disorder is the highest cause of disability globally and at least one-third of MDD patients meet the criteria for TRD, a condition characterised by failure to sufficiently improve after trialing two or more antidepressants. There remains a vital need, therefore, to develop novel treatment approaches to TRD that can provide rapid relief of depressive symptoms and also be well tolerated by patients. The primary aim of this platform trial is to compare the effectiveness of a range of new treatments to improve depression symptoms in patients with TRD. Additional aims are to compare quality of life, treatment acceptance, and safety measures. Anticipated treatments to be investigated include psychedelics, neurostimulation, psychological therapy and antidepressant medications. Promising new treatments may be added and inferior treatments removed in the lifetime of the study.
Latest Resource
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Webinar recording: APT Virtual Clinic – SEISMIC and IVCare
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Webinar recording: APT Virtual Clinic – ED Asthma and CAPTIVATE
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Webinar recording: APT Virtual Clinic – ACT-GLOBAL Adaptive Platform Trial for Stroke
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Webinar recording: APT Virtual Clinic – PLATIPUS: A Platform for Adaptive Trials in Perinatal Units
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Webinar recording: APT Virtual Clinic – Schizophrenia Platform for Improving Recovery with Integrated Trials
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Adaptive Design Clinical Trials
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Workshops and Virtual Clinics on Adaptive Platform Trials
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Webinar recording: APT Virtual Clinic – the BAT and PASSPORT Trials
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Exploring greater partnership between Clinical Trial Networks, Clinical Quality Registries and Trial Coordinating Centres with Industry
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Adaptive Platform Trial Summaries
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HEAT Webinar Recording- Economic Evaluation Alongside Adaptive Trials
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Protocols and Statistical Analysis Plans (SAPs) for Adaptive and Platform Trials
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Data and Safety Monitoring Boards Webinar Series: Statistical Principles
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Data and Safety Monitoring Boards Webinar Series: How to plan well and be prepared for the unexpected
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Statistical Analysis Plan (SAP)
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What are the benefits of adaptive designs?
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How do adaptive trial sizes work?
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What is an adaptive clinical trial?
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What is response adaptive randomisation?
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Data Safety and Monitoring Boards (DSMB) for Adaptive Trials Webinar video
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Data Safety and Monitoring Boards (DSMB) for Adaptive Trials Webinar slides
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Bayesian adaptive randomised clinical trials flyer
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Adaptive Design Clinical Trials
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Hackathon of Novel Trial Designs part two
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Hackathon of Novel Trial Designs part one
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Studies Within A Trial SWATs webinar
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Innovative Trial Design and Conduct Reference Group Objectives and Directions
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Novel approaches to healthcare effectiveness research outside Australia