Registry-based trials (RBTs) leverage existing clinical registries to offer faster, cost-effective alternatives; enhancing Australia’s research capacity. However, RBTs face methodological and operational challenges. This presentation provided a detailed look at a project focused on creating a best practice guide to support the planning, execution, and documentation of RBTs. The development of the guide was informed by (i) Scoping review, (ii) National multi-stakeholder expert meeting, and (iii) Semi-structured key informant interviews. Findings from this project also highlight key enablers and challenges to the design and conduct of RBTs in Australia. The resultant guide offers key considerations for trialists and registry operators in designing, conducting, and reporting RBTs.
Latest Resource
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STInG Chat – How to build a career as a clinical trials biostatistician
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Webinar recording: Historical and non-concurrent controls in clinical trials
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CQR Webinar: Enhancing Healthcare through Quality Registries & Digital Health
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STInG Chat – ‘Securing Funding: Tips and Tricks for Investigator Grants’
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Webinar recording: Introduction to Git for Clinical Statisticians
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The processes involved in a Data and Safety Monitoring Board/Committee with special reference to the role of the various statisticians
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CQR Collaboration Hub Newsletter – The Benchmark
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ACTA STInG grant advice for trial statisticians
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ACTA STInGChat – ‘Climbing the Career Cascade’
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Seamless Phase 2_3 Trials in Oncology
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Career paths for academic biostatisticians
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Exploring greater partnership between Clinical Trial Networks, Clinical Quality Registries and Trial Coordinating Centres with Industry – Environmental Scan
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ACTA STInG: N-of-1 Trials Webinar Series – Webinar 2
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ACTA STInG: N-of-1 Trials Webinar Series – Webinar 1
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Effective strategies to manage data integrity risks webinar
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The Data Lifecycle: Ethical use of data webinar
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Transparency in data analyses webinar
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Webinar PIONEERing estimands in Clinical Research
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Estimands: Not just a statistical issue
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Resource for trial statisticians planning to apply for an academic promotion
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Guidance on Peer Reviewing the Statistical Aspects of a Medical Paper
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Protocols and Statistical Analysis Plans (SAPs) for Adaptive and Platform Trials
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Webinar: Estimands in Oncology – How and Why
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Seven steps for statistical success in clinical trials [Good clinical practice guidelines] Part 2
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Seven steps for statistical success in clinical trials [Good clinical practice guidelines] Part 1
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Data and Safety Monitoring Boards Webinar Series: Statistical Principles
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Data and Safety Monitoring Boards Webinar Series: How to plan well and be prepared for the unexpected
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Joint webinar on estimands in clinical trials
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Statistical Analysis Plan (SAP)
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Data Safety and Monitoring Boards (DSMB) for Adaptive Trials Webinar video
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Bayesian adaptive randomised clinical trials flyer
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ACTA STInG Notes from Members’ meeting, October 2019
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ACTA STInG 2017 Member Survey Results
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How can registries drive better translation of real world data into better quality care?
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How can registries drive better translation of real world data into better quality care?
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What we don’t know about the health and economic benefit of trials and registries in Australia