Treatment switching is where patients recruited into a randomised controlled trial (RCT) switch away from the treatment to which they were randomised. This is common in trials of oncology treatments. In health technology assessment (HTA), we need to estimate the clinical and cost-effectiveness of inserting new treatments into the treatment pathway. If the treatment pathways followed in the RCT from which we are taking evidence does not reflect the treatment pathways that would be followed in clinical practice, standard intention-to-treat (ITT) analyses will not provide the evidence we need to inform HTA decision-making. Instead, we need to estimate outcomes that would have been observed had relevant treatment pathways been followed, which may involve needing to adjust for treatment switches that occurred in the RCT. This talk will discuss when and how we may need to use methods to adjust for treatment switching in oncology trials.
Latest Resources
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HEAT SIG webinar Economic evaluation alongside clinical trials in the anthropocene
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ACTA webinar – Estimating inequalities in health using quality-adjusted life expectancy: equity implications for health technology assessment and clinical trials
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Developing ModRUM: a standardised, generic, modular resource-use measure
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ACTA Webinar – Discrete choice experiment checklist
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Development of the Cost-IS (costing implementation strategies) instrument
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Webinar recording: The economics of trials – reducing waste in research
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Webinar recording: Identifying and addressing trial design issues early
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ACTA Webinar: Pre-trial VOI analyses to guide trial prioritisation and data collection
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Webinar recording: Patient reported outcome endpoints: Optimal development, collection, analysis planning & reporting:
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Webinar recording: Quantifying Equity Impacts
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HEAT webinar recording: Design of economic evaluations along the development process
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HEAT Webinar Recording-Flexible survival models and why we (might) need them
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HEAT Webinar Recording- Use of Administrative Data for Measuring Events and Healthcare Use
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HEAT Webinar Recording- Economic Evaluation Alongside Adaptive Trials
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A pilot study to prospectively estimate the health and economic return on research investment
Latest Events
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ACTA Webinar – Conducting economic evaluation alongside paediatric clinical trials: special considerations and examples
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ACTA webinar – Estimating inequalities in health using quality-adjusted life expectancy: equity implications for health technology assessment and clinical trials
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ACTA 2025 Clinical Trials and Registries Symposium
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ACTA Developing ModRUM: a standardised, generic, modular resource-use measure
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ACTA Webinar – Discrete choice experiment checklist
-
ACTA Webinar – Development of the Cost-IS (costing implementation strategies) instrument
-
ACTA Health economics alongside trials webinar: Identifying and addressing trial design issues early
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ACTA Webinar: Pre-trial VOI analyses to guide trial prioritisation and data collection
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Patient reported outcome (PRO) endpoints: Optimal development, collection, analysis planning and reporting
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Webinar: Quantifying Equity Impacts