The growing adoption of Bayesian adaptive designs in clinical research reshaped and expanded the roles of both DSMBs and trial investigators. This webinar explored the dynamic collaboration between DSMBs and investigators, focusing on how almost real-time data, adapting trial design, ongoing publications of selected results, and ethical oversight intersected in platform trials. Participants unpacked practical challenges, communication pathways, and governance strategies essential to safeguarding trial integrity while maximising efficiency and innovation. Key topics included prioritising data quality, managing information flow, maintaining trial integrity, implementing adaptations based on decision criteria, and aligning safety monitoring with evolving trial evidence. The session highlighted case examples and emerging best practices that supported robust oversight in a dynamic trial landscape.
Latest Resource
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The challenges of stopping trials for benefit: Lessons learnt from the immediate Kangaroo Mother Care (iKMC) trial – Part 2
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STInG Chat – What makes this trial great?
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Platform trials: key features, when to use them and methodological challenges
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Interim Data Sharing by Data Safety Monitoring Board: What to share, with whom, and why
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Data Integrity Tool for assessing the integrity of randomised trials
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The value of getting involved with ACTA STInG
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Winner of the ACTA STInG Excellence in Trial Statistics award shares how ACTA STInG provided valuable networking opportunities during the pandemic
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Data and Safety Monitoring Board (DSMB) Mentoring Program
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ACTA Webinar – Developing a Best Practice Guide for Registry Based Trials
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STInG Chat – How to build a career as a clinical trials biostatistician
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Webinar recording: Historical and non-concurrent controls in clinical trials
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STInG Chat – ‘Securing Funding: Tips and Tricks for Investigator Grants’
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Webinar recording: Introduction to Git for Clinical Statisticians
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The processes involved in a Data and Safety Monitoring Board/Committee with special reference to the role of the various statisticians
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ACTA STInG grant advice for trial statisticians
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ACTA STInGChat – ‘Climbing the Career Cascade’
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Seamless Phase 2_3 Trials in Oncology
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Career paths for academic biostatisticians
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ACTA STInG: N-of-1 Trials Webinar Series – Webinar 2
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ACTA STInG: N-of-1 Trials Webinar Series – Webinar 1
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Effective strategies to manage data integrity risks webinar
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The Data Lifecycle: Ethical use of data webinar
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Transparency in data analyses webinar
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Webinar PIONEERing estimands in Clinical Research
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Estimands: Not just a statistical issue
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Resource for trial statisticians planning to apply for an academic promotion
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Guidance on Peer Reviewing the Statistical Aspects of a Medical Paper
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Protocols and Statistical Analysis Plans (SAPs) for Adaptive and Platform Trials
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Webinar: Estimands in Oncology – How and Why
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Seven steps for statistical success in clinical trials [Good clinical practice guidelines] Part 2
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Seven steps for statistical success in clinical trials [Good clinical practice guidelines] Part 1
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Data and Safety Monitoring Boards Webinar Series: Statistical Principles
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Data and Safety Monitoring Boards Webinar Series: How to plan well and be prepared for the unexpected
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Joint webinar on estimands in clinical trials
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Statistical Analysis Plan (SAP)
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Data Safety and Monitoring Boards (DSMB) for Adaptive Trials Webinar video