Adaptive Trials Workshop — Thursday the 22nd March 2018, Melbourne
The Australian Clinical Trials Alliance – Statistics In Trials Interest Group (ACTA-STInG), the ACTA Innovative Trials Design, the Melbourne Academic Centre for Health (MACH), and Conduct Reference Group and the Biostatistics Section of the Statistical Society of Australia (SSA) are hosted an Adaptive Trials Workshop on the 22nd March 2018.
This workshop brought together statisticians and clinicians with an interest in adaptive clinical trial designs to share knowledge and information about current research in adaptive designs and their application. The morning provideed an introduction to adaptive designs, ranging from traditional frequentist to innovative platform trials, including the statistical issues and the challenges of utilising such designs. In the afternoon four researchers who had experience in running adaptive trials presented examples of their trials. The day included plenty of time for discussion, ending with a panel discussion about “Where to from here?”
Thursday 22nd March 2018
Ella Latham Theatre
Ground Floor, Royal Children's Hospital
Parkville, VIC, 3052
Click here to view Workshop Timetable
Writing Clinical Trial Simulators Workshop -- Friday 23rd March, Melbourne
There was be an additional, half-day Writing Clinical Trial Simulators Workshop on the morning of Friday the 23rd of March about conducting simulations for platform trials.
The use of simulation is growing in the design of clinical trial designs as an augmentation of, or replacement for, sample size calculations. Usually this is in order to be able to: estimate operating characteristics of the planned trial other than simply power, to be able to estimate actual type-1 error and power taking into account factors such as the effect of dropouts, and to be able to use trial designs that are too complex for sample size calculation such as adaptive designs. This course introduced statisticians to the concepts, software, and engineering skills required to write and use a trial simulator. It was intended for statisticians with some programming experience (e.g. R, SAS), to introduce them to design considerations of writing a simulator and testing whether the simulator is correct. The course taught how to use simulations to engineer and guide design decisions, including the importance of simulating single example trials and summarizing key operating characteristics across many simulations. It will also focus on effective communication strategies for presenting simulation results to clinical colleagues.
The aims of this course were to help partcipants:
• Understand what clinical trial simulation is and the vital role it plays in the development of a clinical trial design
• Have the foundational tools to start writing and testing clinical trial simulators
• Appreciate the value of reviewing individual simulated trials
• Understand how to present operating characteristics summarized across many simulated trials
Click here to view Workshop Timetable
Friday 23rd March 2018
Room 1.036, Level 1 HELP
Royal Children's Hospital
Parkville, VIC, 3052