In 2018, ACTA’s Reference Group on Embedding Clinical Trials in Healthcare produced a report mapping international approaches to embedding clinical trials into the healthcare system. 
 
These learnings become increasingly relevant now, and many of our existing hospital-based clinical trial networks could be best placed to implement pragmatic trials of antiviral treatments or other interventions directly into routine clinical care delivery.
 
The embedding report is available on the ACTA website in our resource area:

Many treatments and treatment strategies enter routine clinical practice without evidence of effectiveness or of cost-effectiveness. This vacuum of evidence contributes to variation in care and unsustainable growth in healthcare expenditure. There is also widespread evidence that many treatments that have been proven to be effective and cost-effective are not implemented in clinical practice. Although many systems have been proposed as best practice to embedding clinical trials in routine practice, the concept of a Learning Healthcare System (LHS) is gaining traction internationally as the way to achieve the best possible patient outcomes at reasonable cost. An LHS is characterised by continuous generation and implementation of knowledge from clinical research embedded within healthcare delivery. Through an international scoping exercise, ACTA identified that moving successfully to an LHS requires buy-in from all stakeholders, including health system leaders and health professionals who are not research-active, and that all stakeholders should value clinical trials as part of an LHS and be able to convey their importance to patients and the public.