REMAP-CAP: A multi-factoral, multi-intervention, multi-strata Bayesian adaptive trial
Presented by Professor Steve Webb
This trial tests up to 5 different antibiotics, 2 durations of macrolide therapy, 2 approaches to corticosteroid treatment, and 4 different approaches to mechanical ventilation in patients with or without septic shock who have severe Community Acquired Pneumonia. It is designed to be a perpetual trial with new domains and interventions added as questions in the launch domains are answered, using response-adaptive randomisation to increase the likelihood patients receive better treatments, and with in-built translation of results into practice once any intervention is identified as superior.