Support CTNs to transition from the use of conventional trial designs to the use of innovative trial designs where appropriate.
- Facilitate the availability, dissemination, uptake, and evaluation of innovative methods of trial design
- Influence policy and promote the development of shared infrastructure that can support innovative trial design
Recent group activities:
- Most of the outputs for this group are academic and educational events. In early 2019 this reference group held a number of events as part of the ACTA ‘Summer School’ and also hosted a number of webinars as part of ‘Webinar Wednesday’
- Summer School events:
- Introduction to Innovative Trial Designs, one day seminar (SYD)
- Innovative Trial Design Clinic, half-day (SYD)
- Adaptive clinical trial designs: theory and hands-on skills development, two-day workshop (SYD, MEL, BNE)
- Webinars include:
- Studies Within A Trial (SWAT)
- Hackathon of trial designs
- FDA guidance for novel trials (Scott Berry)
Latest Resources
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Webinar recording: APT Virtual Clinic – ED Asthma and CAPTIVATE
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Webinar recording: APT Virtual Clinic – ACT-GLOBAL Adaptive Platform Trial for Stroke
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Webinar recording: APT Virtual Clinic – UNSW / Black Dog Institute on Treatment-Resistant Depression
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Webinar recording: APT Virtual Clinic – PLATIPUS: A Platform for Adaptive Trials in Perinatal Units
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Webinar recording: APT Virtual Clinic – Schizophrenia Platform for Improving Recovery with Integrated Trials
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Adaptive Design Clinical Trials
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Workshops and Virtual Clinics on Adaptive Platform Trials
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Webinar recording: APT Virtual Clinic – the BAT and PASSPORT Trials
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Exploring greater partnership between Clinical Trial Networks, Clinical Quality Registries and Trial Coordinating Centres with Industry
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Protocols and Statistical Analysis Plans (SAPs) for Adaptive and Platform Trials
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Data and Safety Monitoring Boards Webinar Series: Statistical Principles
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Data and Safety Monitoring Boards Webinar Series: How to plan well and be prepared for the unexpected
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Statistical Analysis Plan (SAP)
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What are the benefits of adaptive designs?
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How do adaptive trial sizes work?
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What is an adaptive clinical trial?
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What is response adaptive randomisation?
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Data Safety and Monitoring Boards (DSMB) for Adaptive Trials Webinar video
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Data Safety and Monitoring Boards (DSMB) for Adaptive Trials Webinar slides
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Bayesian adaptive randomised clinical trials flyer
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Adaptive Design Clinical Trials
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Hackathon of Novel Trial Designs part two
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Hackathon of Novel Trial Designs part one
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Studies Within A Trial SWATs webinar
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Innovative Trial Design and Conduct Reference Group Objectives and Directions
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Novel approaches to healthcare effectiveness research outside Australia
Latest News
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AusTriM Innovative Methods in Trials – Design & Analysis Collaboration Opportunity
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Webinar wrap-up: Data Safety and Monitoring Boards for Adaptive Trials
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International experts head to Melbourne and Sydney for Bayesian Adaptive Trials Workshop
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ACTA Webinar: Scott Berry on the FDA Adaptive Trial Guidance
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ACTA Hackathon of Novel Trial Designs webinars: 1 and 15 May
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Announcing ACTA’s new Summer School and Weekly Webinars
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ACTA’s Innovative Trial Design and Conduct Reference Group innovates into two
Latest Events
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ACTA Virtual Clinics on Adaptive Platform Trials 2024
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Platform trials and master protocols – Workshop
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Improving clinical trial recruitment through innovative technologies
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Practical approaches to Adaptive Trial Simulation
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An Introduction to Adaptive Trial Designs
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Seven steps for statistical success in clinical trials [Good clinical practice guidelines] Part 1
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Statistical principles – Data and Safety Monitoring Boards Webinar Series
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How to plan well and be prepared for the unexpected – Data and Safety Monitoring Boards Webinar Series
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Webinar: Data Safety and Monitoring Boards for Adaptive Trials
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Bayesian Adaptive Randomised Clinical Trials Workshop, Sydney
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Bayesian Adaptive Randomised Clinical Trials Workshop, Melbourne
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Bayesian Adaptive Trials Workshops: Perth
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Workshop: Pragmatic randomised trial designs for evaluating health policy and practice change interventions