Impact and Implementation of Clinical Trial Networks

Maximise and measure the value of clinical trials to the community and the healthcare system, including the consideration of the implementation of trial results into standard care.

  • Establish a community of practice involving both clinical trial networks, experts in implementation science, and end-users to grow capacity in networks to facilitate effective implementation of trial results conducted by networks
  • Disseminate and promote methods to clinical trial networks to facilitate trial design that optimises capacity for implementation, to measure impact on practice, including economic impact following implementation of trial results (i.e. return-on-investment studies)

Recent group activities:

  • Scope and definitions of the group were developed by leadership group early 2018
  • Impact and Implementation forum held in August 2018 with national and international speakers
  • A survey of all networks to establish how much they consider implementability and implementation as part of their trial designs
  • A report stemming from the survey results

Current activities:

A literature review of published studies assessing Implementability is in the final stages of writing. The group is hoping to publish a condensed version in a medical journal.

The group is in the final stages of publishing three guidance documents for trialists. These will be published in full on the ACTA website and then condensed summaries submitted for publication in a medical journal. These documents will come under the following headings:

  • Optimising for implementation
    • What next after the trial?
    • Measuring implementation

Future activities:

  • The group is planning to present its work to the Department of Health at its next meeting with ACTA
  • They will develop a tool to measure the impact of trials and training on the use of the tool
  • The group hopes to evaluate key issues in the measurement of impact in trial funding proposals

Group Leadership

  • Prof Alan Cass
  • Prof Sally Green
  • Prof Christopher Levi
  • Prof Steve Webb


  • Dr Karen Best
  • Prof Frank Bloomfield
  • Dr Paul Cohen
  • A/Prof Sue Crengle
  • Dr Dashiell Gantner
  • Adj Prof Davina Ghersi
  • Prof Paul Glasziou
  • Ms Tiffany Harris‐Brown
  • Prof Stephen Jan
  • Prof David Johnson
  • Prof Samantha Keogh
  • A/Prof Philippa Middleton
  • Prof Sandra Peake
  • Dr Angela Scheppokat
  • Prof Paul Scuffham
  • Mr Greg Sharplin
  • Prof Tim Shaw
  • Prof David Story
  • Prof Helena Teede
  • Mrs Val Theisz
  • A/Prof Judith Trotman
  • Dr Carolina Weller
  • Ms Anne Woollett
  • Prof Sophia Zoungas
  • Ms Neina Fahey

Project Officer

Dr Ann Wilson

Board Sponsors

  • Prof Steve Webb
  • Ms Anne McKenzie

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